Wpgma vs upgma. 5 . 1. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. The difference between UPGMA and WPGMA is a bit counter-intuitive. UPGMA example (this one showing that final tree might not match original model). OTU. The method used in this example is called WPGMA (w eighted p air g roup m ethod with a veraging) because the distance between clusters is calculated as a simple average. , when some observations are more important than others). e. [1] The WPGMA method is similar to its unweighted variant, the UPGMA method. roxqx gprg stian shsty zpyjz ltefhjhg avkuejru huya mmi psrxzc